Chikwata chenyika dzevaongorori vekuEurope chawana solanimycin, mushonga mutsva unorwisa fungal. Chinhu, icho chakatanga kuparadzaniswa kubva kune pathogenic bhakitiriya inobata mbatatisi, inoita seinogadzirwa nemhando dzakasiyana dzezvirimwa pathogenic bacteria.
Maererano nevatsvakurudzi, solanimycin inoshanda pakurwisana nehuwandu hwehutachiwana hunozivikanwa kuti hunokanganisa nekuparadza zvirimwa. Mune bvunzo dzeLab, iyo komboni yakavharisawo Candida albicans, fungus inowanzoitika mumuviri asi inogona kukonzera hutachiona hune njodzi. Solanimycin nemakomisheni ane hukama anogona kubatsira mune zvese zvekurima uye zvekiriniki, maererano nezvakawanikwa.
Sekureva kwenyanzvi yezvipenyu zvisingaoneki, Rita Monson, Ph.D., wekuYunivhesiti yeCambridge, kuwanikwa kunoratidza kuti microorganisms zvakakosha kuti tiongorore zvakanyanya, kunyanya sezvo zvirimwa zvichikura kusawirirana nemishonga iripo. Akatungamira tsvagiridzo iyi nemuongorori wemomecular microbiologist Miguel Matilla, Ph.D., paEstación Experimental del Zaidn yeSpanish Research Council muGranada.
Solanimycin harisi mushonga wekutanga kuwanikwa kubva kuutachiona. Ongororo yapfuura yakawana kuti D. solani inogadzira mushonga unorwisa mabhakitiriya unonzi oocydin A, unoshanda zvakanyanya kurwisa hosha dzakasiyana siyana dzezvirimwa.
Izvi zvakambowanikwa, pamwe nekuongororwa kwejenome rebhakitiriya, zvakaratidza kuti inogona kugadzira mamwe maantibioti, pamwe neanopesana nefungal properties, maererano nenyanzvi dzataurwa pamusoro apa. Vakaona kuti pavakanyaradza majini ane chekuita neoocydin A kugadzirwa, bhakitiriya rakachengeta anti-fungal chiitiko. Kucherechedza ikoko kwakatungamirira pakuzivikanwa kwe solanimycin uye kuzivikanwa kwemasumbu ejini anokonzera mapuroteni anoita musanganiswa.
Vatsvakurudzi vakawana kuti bhakitiriya rinogadzira musanganiswa zvishoma mukupindura kusimba kwesero. Iyo solanimycin gene cluster inoshandiswawo mune acidic pH nharaunda, senge inowanikwa mumatato. Maererano naMonson, inoratidzika senzira yekudzivirira yakangwara.
"Iyo antifungal yatinotenda kuti ichashanda nekuuraya fungal vakwikwidzi, uye mabhakitiriya anobatsirwa zvakanyanya kubva pane izvi. Asi haubatike kunze kwekunge uri mumbatatisi,” Monson akadaro.
Vatsvakurudzi vatanga kushanda nemakemikari kuti vadzidze zvakawanda nezve molecule ye solanimycin uye kuti inoshanda sei. Ipapo, vakaratidzira chishuvo chavo chokuti komboni yacho iongororwezve mumienzaniso yemiti nemhuka.
“Matanho edu emangwana akanangana nekuedza kushandisa mushonga uyu unorwisa fungal kudzivirira chirimwa. Tinofanira kuvhura kuongororwa kwezvese zviri kunze uko kuti tiwane mishonga mitsva yemishonga,” Matilla akapedzisa.
Makore anopfuura gumi nemashanu apfuura, bhakitiriya repathogenic mbatatisi Dickeya solani, iro rinogadzira solanimycin, rakawanikwa. Makore gumi apfuura, vaongorori murabhoritari yemolecular microbiologist George Salmond, Ph.D., paUniversity yeCambridge akatanga kuongorora kugona kwayo kwemishonga inorwisa mabhakitiriya.
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